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Synthesis 2000; 2000(4): 541-544
DOI: 10.1055/s-2000-6371
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An Elegant Approach Towards the Regioselective Synthesis of Deazalumazines Through Nucleophile Induced Ring Transformation Reactions of 6-Aryl-3-cyano-4-methylthio-2H-pyran-2-ones

Pratibha Srivastava* , Abhishek S. Saxena, Vishnu J. Ram
  • *Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226001, India; Fax +91 (5 22) 22 34 05; E-mail: root@cscdri.ren.nic.in
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Publikationsdatum:
31. Dezember 2000 (online)

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Deazalumazines also known as pyrido[2,3-d]pyrimidines (3) have been regioselectively synthesized through nucleophile induced ring transformation reactions of 6-aryl-3-cyano-4-methylthio-2H-pyran-2-ones (1) with 6-amino-1,3-dimethyluracil (2).

6-aryl-3-cyano-4-methylthio-2H-pyran-2-ones - 6-amino-1,3-dimethyluracil - ring transformation reactions - regioselective synthesis - condensation - heterocycles

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