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Semin Reprod Med 2000; 18(1): 091-096
DOI: 10.1055/s-2000-13479
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Molecular Analysis of Implantation

Randall S. Hines
  • Department of Obstetrics & Gynecology, University of Mississippi Medical Center, Jackson, Mississippi
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Publication History

Publication Date:
31 December 2000 (online)

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ABSTRACT

The great frontier in reproductive medicine is implantation biology. The scientific understanding of normal implantation lags behind what is known in areas such as fertilization. For obvious reasons this process is difficult to analyze. Recent investigations utilizing molecular biology approaches have scratched the surface of the interaction between the developing trophoblast and the receptive endometrium. This article describes these approaches with techniques such as serial analysis of gene expression (SAGE) and complementary DNA array hybridization, which will soon reveal the key mediators of normal implantation and result in an understanding of failed implantation.

KEYWORD

molecular biology - endometrium - trophoblast - genetics

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