Background and Study Aims: A clean colon is essential for an efficient examination.
The aim of this study was to compare a novel low-dose, low volume triple regimen with
Fleet Phospho-soda.
Methods: A blinded, experienced colonoscopist examined 132 consecutive patients randomly
allocated to receive either a triple regimen consisting of senna syrup (sennoside
B), Picolax (sodium picosulphate), and Klean Prep (polyethylene glycol 3350), or Fleet
Phospho-soda (sodium dihydrogen phosphate and disodium phosphate dodecahydrate). The
colonoscopist recorded cleanliness according to a scoring system (1 - very clean to
4 - solid stools), and time taken to reach the caecum.
Results: In the triple regimen group (n = 81), 73 % scored 1 or 2 compared with 57
% in the Fleet Phospho-soda group (n = 51, p = 0.037 Mann-Whitney U-test). Examination
to caecum was achieved in 95 % of the triple regimen group and 89 % of the Fleet Phospho-soda
group. Among those examined as far as the caecum, the time to reach the caecum was
11 minutes (range 5 - 50) in the triple regimen group compared with 16 minutes (range
5 - 65) in the Fleet Phospho-soda group (p = 0.08, Mann-Whitney U-test). Patient tolerability
was not assessed in this study.
Conclusions: This novel triple regimen produces a cleaner colon than Fleet Phospho-soda,
is associated with a trend towards a quicker and more efficient colonic examination,
and is also 30 % cheaper per patient.
References
ChukaNwokolo@compuserve.com
