Planta Med 2000; 66(1): 16-19
DOI: 10.1055/s-2000-11114
Original Paper
Georg Thieme Verlag Stuttgart · New York

The 5α-Reductase Inhibitory Components from Heartwood of Artocarpus incisus: Structure-Activity Investigations

Kuniyoshi Shimizu, Masayuki Fukuda, Ryuichiro Kondo*, and, Kokki Sakai
  • Department of Forest Products, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Abstract

The methanol extract of heartwood of Artocarpus incisus showed potent 5α-reductase inhibitory activity. We investigated the 5α-reductase inhibitory effects of nine compounds isolated from A. incisus. Chlorophorin (IC50 = 37 μM) and artocarpin (IC50 = 85 μM) showed more potent inhibitory effects than did α-linolenic acid, which is known as a naturally occurring potent inhibitor. Structure-activity investigations suggested that the presence of an isoprene substituent (prenyl and geranyl) would enhance 5α-reductase inhibitory effects.

References

Dr. Ryuichiro Kondo

Department of Forest Products

Faculty of Agriculture

Kyushu University

Fukuoka, 812-8581

Japan

Email: kondo@agr.kyushu-u.ac.jp

Phone: +81-92-642-2989