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DOI: 10.1055/s-2000-11114
The 5α-Reductase Inhibitory Components from Heartwood of Artocarpus incisus: Structure-Activity Investigations
Publication History
Publication Date:
31 December 2000 (online)
Abstract
The methanol extract of heartwood of Artocarpus incisus showed potent 5α-reductase inhibitory activity. We investigated the 5α-reductase inhibitory effects of nine compounds isolated from A. incisus. Chlorophorin (IC50 = 37 μM) and artocarpin (IC50 = 85 μM) showed more potent inhibitory effects than did α-linolenic acid, which is known as a naturally occurring potent inhibitor. Structure-activity investigations suggested that the presence of an isoprene substituent (prenyl and geranyl) would enhance 5α-reductase inhibitory effects.
Key words
Artocarpus incisus L. f. - Moraceae - heartwood - 5α-reductase inhibitor - structure-activity relationship
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Dr. Ryuichiro Kondo
Department of Forest Products
Faculty of Agriculture
Kyushu University
Fukuoka, 812-8581
Japan
Email: kondo@agr.kyushu-u.ac.jp
Phone: +81-92-642-2989