Planta Med 2000; 66(1): 40-43
DOI: 10.1055/s-2000-11109
Original Paper
Georg Thieme Verlag Stuttgart · New York

β-Glucuronidase Inhibitory Activity and Hepatoprotective Effect of 18β-Glycyrrhetinic Acid from the Rhizomes of Glycyrrhiza uralensis

Sang-Bum Shim1 , Nam-Jae Kim2, and, Dong-Hyun Kim1,*
  • 1 College of Pharmacy, Kyung Hee University, Seoul, Korea
  • 2 East-West Medical Institute, Kyung Hee Medical Center, Kyung Hee University, Seoul, Korea
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Abstract

An inhibitor of β-glucuronidase from the rhizomes of Glycyrrhiza uralensis was isolated and its hepatoprotective activity on CCl4-induced hepatotoxicity of rats was investigated. From the water-soluble extract of G. uralensis, glycyrrhizin was isolated as a potent inhibitor of β-glucuronidase. When glycyrrhizin was orally administered, it had a hepatoprotective activity. However, when glycyrrhizin was intraperitoneally administered, it did not have a hepatoprotective activity. 18β-Glycyrrhetinic acid, which is a major metabolite of glycyrrhizin by human intestinal bacteria, was also a potent inhibitor of β-glucuronidase. When 18β-glycyrrhetinic acid was intraperitoneally administered, it also had some hepatoprotective activity. These results suggest that glycyrrhizin may be a natural prodrug for the observed hepatoprotective effect in rats and that serum β-glucuronidase levels have implications for the liver injury, as reductions of its activity by administration of inhibitors such as G. uralensis or its derived products and silymarin correlate with reductions in biochemical indices of liver injury.

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Prof. Dr. D.-H. Kim

College of Pharmacy

Kyung Hee University

1 Hoegi, Dongdaemun-ku

Seoul 130-701

Korea

Email: [email protected]

Phone: +82 2-957-5030