Int J Sports Med 1999; 20(3): 198-200
DOI: 10.1055/s-1999-970289
Orthopedics and Clinical Science

© Georg Thieme Verlag Stuttgart · New York

Clinical Sciences and Orthopaedics: Case Report Homozygous APC Resistance in an Elite Athlete

T. Hilberg1 , C. Moessmer2 , M. Hartard1 , D. Jeschke1
  • 1Policlinic for Preventive and Rehabilitative Sports Medicine
  • 2Institute for Clinical Chemistry and Pathobiochemistry, Technische Universitat Miinchen
Further Information

Publication History

Publication Date:
03 August 2007 (online)

We report the case of a 31 year old female elite athlete. During a routine check-up including a search for hereditary hemostatic risk factors for thrombosis, resistance to activated protein C was detected. Molecular analysis of the factor V gene revealed homozygosity for the factor V Leiden mutation. This is the first documented case of an elite athlete who is a homozygous carrier of factor V Leiden. Elite athletes may be exposed to several circumstantial thrombogenic risk factors and, therefore, special preventive measures in carriers of a congenital risk factor such as APC resistance are indicated. Essential measures are early anticoagulation during periods of immobilisation e.g. after sports-related injuries, a single dose of low-molecular-weight heparin specially for individuals with several thrombotic risk factors and/or leg muscle exercises for long-distance (air) travels and avoiding haemoconcentration with a sufficient oral fluid intake.