Int J Sports Med 1999; 20(8): 503-509
DOI: 10.1055/s-1999-8835
Physiology and Biochemistry
Georg Thieme Verlag Stuttgart ·New York

Effects of Calcium â-Hydroxy-â-methylbutyrate (HMB) Supplementation During Resistance-Training on Markers of Catabolism, Body Composition and Strength

 R. B. Kreider1 ,  M. Ferreira1 ,  M. Wilson1 ,  A. L. Almada2
  • 1 Exercise & Sport Nutrition Laboratory, Department of Human Movement Sciences & Education, The University of Memphis, Memphis, USA
  • 2 Experimental & Applied Sciences, Inc., Golden, Colorado, USA
Further Information

Publication History

Publication Date:
31 December 1999 (online)

Calcium â-hydroxy-â-methylbutyrate (HMB) supplementation has been reported to reduce muscle catabolism and promote gains in fat-free mass and strength in subjects initiating training. However, whether HMB supplementation promotes these adapations in trained athletes is less clear. This study examined the effects of HMB (as the calcium salt) supplementation during resistance training (6.9 ± 0.7 hr × wk-1) on markers of catabolism, body composition and strength in experienced resistance-trained males. In a double-blind and randomized manner, 40 experienced resistance-trained athletes were matched and assigned to supplement their diet for 28 d with a fortified carbohydrate/protein powder containing either 0, 3 or 6 g × d-1 of calcium HMB. Fasting venous blood and urine samples, dual energy X-ray absorptiometer-determined body composition, and isotonic bench press and leg press one repetition maximums (1 RM) were determined prior to and following 28 d of supplementation. HMB supplementation resulted in significant increases in serum and urinary HMB concentrations. However, no statistically significant differences were observed in general markers of whole body anabolic/catabolic status, muscle and liver enzyme efflux, fat/bone-free mass, fat mass, percent body fat, or 1 RM strength. Results indicate that 28 d of HMB supplementation (3 to 6 g × d-1) during resistance-training does not reduce catabolism or affect training-induced changes in body composition and strength in experienced resistance-trained males.


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FACSM PhD Richard B. Kreider

Exercise & Sport Nutrition Laboratory Department of Human Movement Sciences & Education The University of Memphis

Memphis, TN 38152


Phone: +1 (901) 678-3474

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