Nonsteroidal anti-inflammatory drugs (NSAID) account for a large part of prescriptions
and self-administered medication worldwide. The adverse effects on the upper gastrointestinal
tract are well documented. However, in an increasing number of publications adverse
effects in the small and large intestine distal to the duodenum are being reported.
This paper provides an updated review of current as well as earlier literature on
the pathogenesis of such adverse effects and the potential damage to the small and
large bowel caused by NSAID. In addition, suggestions for an appropriate diagnostic
workup of NSAID damage are discussed.
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