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Synthesis 1999; 1999(1): 66-68
DOI: 10.1055/s-1999-3694
short paper
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Lewis Acid-Mediated Selective Removal of N-tert-Butoxycarbonyl Protective Group (t-Boc)

D. Subhas Bose* , V. Lakshminarayana
  • *Organic Chemistry Division III, Indian Institute of Chemical Technology, Hyderabad 500 007, India; Fax +91-40-7 17 33 87/7 17 37 57; E-mail: root@csiict.ren.nic.in
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Publikationsdatum:
31. Dezember 1999 (online)

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A simple and efficient method for the selective cleavage of N-Boc protective groups from amines employing Lewis acid aluminum chloride, is described. The scope of this procedure is explored for the deprotection of a variety of amines including amino acid derivatives.

aluminum chloride - t-Boc carbamates - selective cleavage