Synlett 1999; 1999(6): 729-730
DOI: 10.1055/s-1999-2731
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Efficient Synthesis of Aromatic sec-Amides from Esters: Synthetic Utility of Bislithium Amides

Takashi Ooi* , Eiji Tayama, Masao Yamada, Keiji Maruoka
  • *Department of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan; Fax +81 (11) 7 46 25 57; E-mail: maruoka@sci.hokudai.ac.jp
Further Information

Publication History

Publication Date:
31 December 1999 (online)

Convenient, efficient preparation of aromatic sec-amides from esters has been accomplished using dilithium amides which are easily prepared by treatment of aromatic amines with 2 equiv of BuLi in THF. This new method allows a facile formation of amide bond even with sterically hindered esters.

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