Download PDF
Synlett 1999; 1999(5): 573-575
DOI: 10.1055/s-1999-2697
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthetic Study on Top-Half (C14-C25) Fragment of Amphidinolide B, a 26-Membered Macrolide

Katsuhide Ohi* , Shigeru Nishiyama
  • *Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi, Yokohama 223-8522, Japan; Fax +81-45-5 63-59 67; E-mail: nisiyama@chem.keio.ac.jp
Further Information

Publication History

Publication Date:
31 December 1999 (online)

 PDF Download  Permissions and Reprints All articles of this category

The top-half fragment (C14-C25) of amphidinolide B, a potent cytotoxic macrolide isolated from the marine dinoflagellate Amphidinium sp., has been synthesized using a coupling reaction of iodide 16 corresponding to the C14-C19 part and α,β-unsaturated dithioacetal 9 possessing the remaining carbon framework (C20-C25) as the key step.

marine natural products - Amphidinolide B - cytotoxic activity - umpolung - asymmetric dihydroxylation