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Synlett 1999; 1999(4): 432-434
DOI: 10.1055/s-1999-2632
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Aldol Reactions of Acylsilanes and Difluoroenoxysilanes. Application to the Synthesis of 2-Fluoro-1,3-diketones

Damien Saleur* , Thierry Brigaud, Jean-Philippe Bouillon, Charles Portella
  • *Laboratoire "Réactions Sélectives et Applications", Associé au CNRS (UMR 6519), Université de Reims, Faculté des Sciences, B.P. 1039, 51687 Reims Cedex 2, France; Fax 3 33 26 05 31 66; E-mail: charles.portella@univ-reims.fr
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Publication Date:
31 December 1999 (online)

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We describe the synthesis of new gem-difluoro-C-silylated aldols from acylsilanes and trifluoromethyltrimethylsilane via an aldol reaction. Their defluorosilylation gives aliphatic and alicyclic 2-fluoro-1,3-diketones. The overall reaction sequence can be considered as a new complementary method giving access to a wide variety of such fluorinated 1,3-diketones.

acylsilane - difluoroenoxysilane - aldol reaction - 1,3-diketone

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