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Planta Med 1999; 65(4): 331-334
DOI: 10.1055/s-1999-14060
Original Paper

Georg Thieme Verlag Stuttgart · New York

Hypotensive, Hypoglycaemic and Toxicological Studies on the Flavonol C-Glycoside Shamimin from Bombax ceiba

Rubeena  Saleem1 , Mohammad  Ahmad1 , Syed Ahmed Hussain1 , Aamer Mahmood Qazi1 , Syed Iqbal Ahmad1 , Mahmood Hussain Qazi1 , Muhammad Ali2 , Shaheen  Faizi2 , Shamim Akhtar3 , Syed Nazrul Husnain3
  • 1Dr. H. M. I. Institute of Pharmacology and Herbal Sciences, Hamdard University, Karachi, Pakistan
  • 2H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan
  • 3VGV;Department of Biochemistry, University of Karachi, Pakistan
Further Information

Publication History

July 22, 1998

January 24, 1999

Publication Date:
31 December 1999 (online)

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Abstract:

Shamimin, a C-flavonol glucoside from Bombax ceiba leaves showed significant potency as a hypotensive agent at the doses of 15 mg/kg, 3 mg/kg, 1 mg/kg and significant hypoglycaemic activity at 500 mg/kg in Sprague-Dawley rats. Further studies revealed that it did not cause any mortality in mice at the dose of 1 g/kg but in rats 500 mg/kg is a lethal dose. Aqueous and methanolic extracts of Bombax ceiba leaves and one of its fractions were also subjected to pharmacological and toxicological screening.

Key words:

Bombax ceiba - Bombacaceae - shamimin - hypotensive activity - hypoglycaemic activity - toxicity