Isoferulic Acid as Active Principle from the Rhizoma of  Cimicifuga dahurica to Lower Plasma Glucose in Diabetic Rats

I.-Min Liu; Tzong-Cherng Chi; Feng-Lin Hsu; Chieh-Fu Chen; Juei-Tang Cheng

doi:10.1055/s-1999-14048

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Planta Med 1999; 65(8): 712-714
DOI: 10.1055/s-1999-14048

Original Paper

Georg Thieme Verlag Stuttgart · New York

Isoferulic Acid as Active Principle from the Rhizoma of Cimicifuga dahurica to Lower Plasma Glucose in Diabetic Rats

I-Min Liu¹ , Tzong-Cherng Chi¹ , Feng-Lin Hsu² , Chieh-Fu Chen³ , Juei-Tang Cheng¹

¹ Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan, R.O.C.
² Department of Medicinal Chemistry, School of Pharmacy, Taipei Medical College, Taipei City, Taiwan, R.O.C.
³ National Research Institute of Chinese Medicine, Taipei City, Taiwan, R.O.C.

Further Information

Publication History

February 11, 1999

June 3, 1999

Publication Date:
31 December 1999 (online)

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Abstract

Isoferulic acid extracted from the rhizome of Cimicifuga dahurica Maxim. (Ranunculaceae) has been determined to have in vivo antihyperglycemic activity. An antihyperglycemic action of isoferulic acid in spontaneously diabetic rats, similar to type I diabetes, is presented.

Key words

Isoferulic acid - Cimicifuga dahurica - Ranunculaceae - glucose challenge - plasma glucose - hyperglycemia - diabetic rats