Aggregation Inhibitory Activity of Minor Acetophenones from  Paeonia Species

Hang-Ching Lin; Hsiou-Yu Ding; Feng-Nien Ko; Che-Ming Teng; Yang-Chang Wu

doi:10.1055/s-1999-14030

Planta Medica, Table of Contents

Planta Med 1999; 65(7): 595-599
DOI: 10.1055/s-1999-14030

Original Paper

Georg Thieme Verlag Stuttgart · New York

Aggregation Inhibitory Activity of Minor Acetophenones from Paeonia Species

Hang-Ching Lin¹ , Hsiou-Yu Ding² , Feng-Nien Ko³ , Che-Ming Teng³ , Yang-Chang Wu⁴

¹ School of Pharmacy, National Defense Medical Center, Taipei, Taiwan
² Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Kaohsiung, Taiwan
³ Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
⁴ Graduate Institute of Natural Products, Kaoshiung Medical College, Kaohsiung, Taiwan

Abstract

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Abstract:

Two minor acetophenones, 2,5-dihydroxy-4-methoxyacetophenone ( 2) and 2,5-dihydroxy-4-methylacetophenone (7) from Paeonia species were found to selectively inhibit the aggregation of rabbit platelets induced by arachidonic acid. They were more potent than the major compound, paeonol (1), and 7 also inhibited the formation of TXA₂ and PGD₂ from arachidonic acid.

Key words:

Acetophenones - Paeonia species - Paeoniaceae - Antiplatelet aggregation

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