Georg Thieme Verlag Stuttgart · New York
Antispasmodic Activity of Thymus vulgaris Extract on the Isolated Guinea-Pig Trachea: Discrimination Between Drug and Ethanol Effects
October 29, 1998
March 14, 1999
31 December 1999 (online)
The effect of an extract of Thymus vulgaris on induced spasms was investigated on guinea-pig trachea preparations. By the experimental setup used, effects of ethanol as the vehicle could be differentiated from the activity of the herbal constituents. The extract reversibly and concentration-dependently antagonized the contraction of the Musculus transversus tracheae, provoked by four different spasmogens (BaCl2, carbachol, histamine, prostaglandin F2α). The degree of the antispasmodic activity was dependent on the individual spasmogen with prostaglandin F 2α being most efficiently antagonized.
Thymus vulgaris - Lamiaceae - guinea-pig trachea - antispasmodic activity - ethanol