Planta Med 1999; 65(6): 512-516
DOI: 10.1055/s-1999-14006
Original Paper

Georg Thieme Verlag Stuttgart · New York

Antispasmodic Activity of Thymus vulgaris Extract on the Isolated Guinea-Pig Trachea: Discrimination Between Drug and Ethanol Effects

Adolf Meister1 , Günther Bernhardt1 , Volker Christoffel2 , Armin Buschauer1
  • 1 Institut für Pharmazie, Universität Regensburg, Regensburg, Germany
  • 2 Plantamed Arzneimittel GmbH, Neumarkt/Opf., Germany
Further Information

Publication History

October 29, 1998

March 14, 1999

Publication Date:
31 December 1999 (online)


The effect of an extract of Thymus vulgaris on induced spasms was investigated on guinea-pig trachea preparations. By the experimental setup used, effects of ethanol as the vehicle could be differentiated from the activity of the herbal constituents. The extract reversibly and concentration-dependently antagonized the contraction of the Musculus transversus tracheae, provoked by four different spasmogens (BaCl2, carbachol, histamine, prostaglandin F). The degree of the antispasmodic activity was dependent on the individual spasmogen with prostaglandin F being most efficiently antagonized.