Acetogenins and Other Compounds from Rollinia emarginata  and Their Antiprotozoal Activities

Anne Février; Maria Elena Ferreira; Alain Fournet; Gloria Yaluff; Alba Inchausti; Antonieta Rojas de Arias; Reynald Hocquemiller; Anne-Isabelle Waechter

doi:10.1055/s-1999-13961

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Planta Med 1999; 65(1): 047-049
DOI: 10.1055/s-1999-13961

Original Paper

Georg Thieme Verlag Stuttgart · New York

Acetogenins and Other Compounds from Rollinia emarginata and Their Antiprotozoal Activities

Anne Février¹ , Maria Elena Ferreira² , Alain Fournet³ , Gloria Yaluff² , Alba Inchausti² , Antonieta Rojas de Arias² , Reynald Hocquemiller¹ , Anne-Isabelle Waechter¹

¹Laboratoire de Pharmacognosie, BIOCIS URA 1843 CNRS, Faculté de Pharmacie, Châtenay-Malabry Cedex, France
²Instituto de Investigaciones en Ciencias de la Salud, Department of Tropical Medicine, AsunciÆn, Paraguay
³Institut de Recherche Scientifique pour le Développement en Coopération, ORSTOM, La Paz, Bolivia

Further Information

Publication History

April 14, 1998

May 30, 1998

Publication Date:
31 December 1999 (online)

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Abstract:

Bioactivity-directed fractionation of the MeOH extract of the stem barks of Rollinia emarginata resulted in the isolation of six compounds, four acetogenins, rolliniastatin-1, sylvaticin, squamocin, and rollidecin B, one lignan, lirioresinol B, and an oxoaporphine, liriodenin. Their structures were determined by spectroscopic analysis and their in vitro leishmanicidal and trypanocidal properties are reported.

Key words:

Rollinia emarginata Schldl. - Annonaceae - acetogenins - Leishmania - Trypanosoma cruzi - Leishmanicidal - trypanocidal