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Planta Med 1999; 65(1): 043-046
DOI: 10.1055/s-1999-13960
Original Paper

Georg Thieme Verlag Stuttgart · New York

Antiviral Tannins from Two Phyllanthus Species

Karin C. S. Chen Liu1 , Mei-Tsu Lin1 , Shoei-Sheng Lee1 , Jwo-Farn Chiou2 , Shijun Ren3 , Eric J. Lien3
  • 1School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, R. O. C.
  • 2Department of Bacteriology, College of Medicine, National Taiwan University, Taipei, Taiwan, R. O. C.
  • 3Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, U. S. A.
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Publikationsverlauf

April 28, 1998

August 2, 1998

Publikationsdatum:
31. Dezember 1999 (online)

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Abstract:

Seven ellagitannins isolated from Phyllanthus myrtifolius and P. urinaria (Euphorbiaceae) have been shown, for the first time, to be active against Epstein-Barr virus DNA polymerase (EBV-DP) at the μM level. All these compounds have the same moiety of a corilagin, and differ from each other by different substitutions at C-2 and C-4 of the glucose core. SAR analysis and molecular modeling reveal that the essential pharmacophore of these tannins resides in the corilagin moiety. The outer complex carboxylic acid moieties appear to act only as auxopharmacore.

Key words:

Phyllanthus myrtifolius - P. urinaria - Euphorbiaceae - Tannins - EBV DNA polymerase - SAR - pharmacophore