Background and Study Aims: The most frequent
complication reported for percutaneous endoscopic gastrostomy (PEG) is peristomal
wound infection which occurs in as many as 30 % of patients. In the
studies published so far, the question of whether antibiotic prophylaxis reduces
the incidence of peristomal wound infection has remained controversial. We
therefore conducted a prospective, randomized trial to determine whether antibiotic
prophylaxis can reduce the incidence of peristomal wound infection associated
with PEG.
Patients and Methods: During a 2-year-period
a total of 347 patients (251 men, 96 women; mean age 60.2 ± 5)
were included in our study. In all cases, a 9-French gauge Freka gastrostomy
tube was inserted using the “pull” technique. The patients were
randomly assigned to three different treatment groups (group 1, antibiotic
prophylaxis with 2 g cefotaxime; group 2, antibiotic prophylaxis with
4 g piperacillin plus 0.5 g tazobactam; group 3, no antibiotic
prophylaxis). For a period of one week after gastrostomy, the peristomal area
was evaluated using a wound score. According to the score, peristomal infections
were classified as being of degree I - IV. Infections
of up to degree III were regarded as minor, while an infection of degree IV
was defined as a severe complication.
Results: PEG tubes were successfully placed
in 336/347 patients (97 %). Of the 336 patients, 29 were excluded because
of incomplete follow up (dropout rate 9 %). Cases included were: in
group 1, n = 101; in group 2, n = 100, and in
group 3, n = 106. There was no mortality related to PEG insertion.
There were five instances of severe complications (1.6 %). Patients
who received antibiotic prophylaxis had mean daily combined wound scores that
were significantly lower than those of patients without antibiotic prophylaxis
(P < 0.01). The control group (no antibiotic prophylaxis)
exhibited significantly more peristomal wound infections of degree III (n = 8)
than antibiotic prophylaxis group 1 (n = 0, P < 0.001)
or antibiotic prophylaxis group 2 (n = 1, P < 0.012).
Three patients in group 3 (no antibiotic prophylaxis) and one patient in group
2 developed peritonitis.
Conclusions: Severe wound infections requiring
medical or endoscopic intervention are very rare events after PEG insertion.
Antibiotic prophylaxis significantly reduces the risk of peristomal wound
infection associated with PEG insertion. Antibiotic prophylaxis, therefore,
is to be recommended as a general measure in percutaneous endoscopic gastrostomy.
