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Synthesis 1997; 1997(5): 541-544
DOI: 10.1055/s-1997-1235
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A Convenient Enzymatic Route to Optically Active 1-Aminoindan-2-ol: Versatile Ligands for HIV-1 Protease Inhibitors and Asymmetric Syntheses

Arun K. Ghosh* , John F. Kincaid, Michael G. Haske
  • *Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607, USA, Fax +1(312)9960431; E-mail: arun.ghosh@uic.edu
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Publication History

Publication Date:
31 December 2000 (online)

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(1S,2R)- and (1R,2S)-1-aminoindan-2-ol were prepared in high enantiomeric excess (>96%) by an immobilized lipase-catalyzed selective acylation of racemic trans-1-azidoindan-2-ol.

enzymatic - resolution - 1-aminoindan-2-ol

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