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Synlett 1996; 1996(12): 1159-1161
DOI: 10.1055/s-1996-5714
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A Versatile A-ring Synthesis for Taxol

Reijo J. Toivola, Ari M. P. Koskinen*
  • *Department of Chemistry, University of Oulu, PO Box 333, FIN-90571 OULU, Finland, Fax: +358-81-553 1629
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Publication History

Publication Date:
31 December 2000 (online)

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Careful A-ring substructure analysis for taxol has been carried out and a practical synthesis to all emergent substructures, viable as A-ring building blocks, has been developed. The synthesis starts from 2-methyl-1,3-cyclohexanedione and enters via ketalized trimethylvinyltriflate and ketalized trimethylester to trimethylketoalcohol(s) with the hydroxyl group protected.

taxanes - palladium - methoxycarbonylation

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