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Synlett 1996; 1996(9): 895-896
DOI: 10.1055/s-1996-5595
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4-Substituted Azetidin-2-ones, New Building Blocks for the Synthesis of β-Lactams

Zbigniew Kałuza* , Sang-Hyun Park
  • *Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland, Fax: +48(22)632 6681, e-mail: ZKIChO@ichf.edu.pl
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Publication Date:
31 December 2000 (online)

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[2+2]Cycloaddition of chlorosulfonyl isocyanate (CSI) to benzylvinyl or divinyl ethers provides new attractive β-lactam building blocks which are subjected to N-alkylation followed by the oxidation of the substituent at C-4 and afford the corresponding 4-acyloxy-N-substituted azetidin-2-ones, suitable for nucleophilic displacement at the C-4-carbon atom.

[2+2]Cycloaddition - chlorosulfonyl isocyanate - β-lactams - 4-acyloxy-N-substituted-azetidin-2-ones

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