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Synlett 1996; 1996(7): 693-694
DOI: 10.1055/s-1996-5544
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Effective Synthesis of α,α-Difluoro Ketones Using ACCUFLUOR TM - NFTh Fluorinating Reagent

Stojan Stavber* , Marko Zupan
  • *Laboratory for Organic and Bioorganic Chemistry, ”JoŽef Stefan” Institute and Department of Chemistry, University of Ljubljana, Jamova 39, 1000 Ljubljana, SLOVENIA, FAX: +386 61 219385
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Publication Date:
31 December 2000 (online)

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Unsaturated cyclic α,α-difluoro ketones were prepared in high yield by the reaction of hydroxy-substituted aromatic derivatives with 1-fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane bis-(tetrafluoroborate) [Accufluor TM - NFTh] in methanol or acetonitrile solution, while α,α-difluoro phenones were obtained from phenylsubstituted alkynes in MeCN/H2O 9:1 reaction media.

fluorination - 1-fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane bis-(tetrafluoroborate) - α,α-difluoro ketones