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Synthesis 1996; 1996(12): 1419-1421
DOI: 10.1055/s-1996-4409
short paper
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Synthesis of Enantiomerically Pure D- and L-Armentomycin and Its Difluoro Analogues from Aspartic Acid

Dirk Winkler1 , Klaus Burger2
  • 1University of Leipzig, Department of Organic Chemistry, Talstr. 35, D-04103 Leipzig, Germany, Fax +49(341)9736599; E-mail winkler@organik.orgchem.uni-leipzig.de
  • 2University of Leipzig, Department of Organic Chemistry, Talstr. 35, D-04103 Leipzig, Germany, Fax +49(341)9736599
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Publication Date:
31 December 2000 (online)

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The synthesis of both enantiomers of 2-amino-4,4-dichlorobutanoic acid (armentomycin) and their fluoro analogues from aspartic acid via 2-amino-4-oxobutanoic acid protected with hexafluoroacetone is described.

aspartic acid - hexafluoroacetone - 2-amino-4-oxobutanoic acid - halogeno α-amino acid - armentomycin

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