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Synthesis 1996; 1996(4): 467-469
DOI: 10.1055/s-1996-4234
short paper
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A Simple and High Yield General Route to Methyl α-Oxo Thiolcarboxylates

Iacopo Degani, Stefano Dughera, Rita Fochi* , Antonella Gatti
  • *Istituto di Chimica Organica dell’Università, via P. Giuria 7, I-10125 Torino, Italy, Fax +39(11)6707642
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Publication History

Publication Date:
31 December 2000 (online)

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Methyl α-oxo thiolcarboxylates (aliphatic, aromatic and heteroaromatic) are obtained in good to excellent yields by hydrolysis of the corresponding trimethyl α-oxo trithioorthoesters with N-bromosuccinimide in aqueous THF or with HgO/35% aqueous HBF4 ves.

α-keto thiolcarboxylates - α-keto trithioorthoesters - hydrolysis

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