One-Pot Procedure for the Synthesis of N-Fumaroyl-2-Oxazolidinones
31. Dezember 2000 (online)
Reaction of maleic anhydride with 2-oxazolidinone in the presence of triethylamine yields mono functionalized maleic acid, which is transformed into functionalized N-fumaroyl-2-oxazolidinones in 45-56% overall yields by treatment with oxalyl chloride and subsequent reaction with nucleophiles.
N-fumaroyl-2-oxazolidinones - chiral Lewis acids - intramolecular Diels Alder reaction