Synlett 1995; 1995(2): 133-141
DOI: 10.1055/s-1995-4882
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Amino Acid Esters: Versatile Chiral Auxiliary Groups for the Asymmetric Synthesis of Nitrogen Heterocycles

Herbert Waldmann*
  • *Universität Karlsruhe, Institut für Organische Chemie, Richard-Willstätter-Allee 2, D-76128 Karlsruhe
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Publication History

Publication Date:
31 December 2000 (online)

The development of amino acid esters as chiral auxiliary groups for the asymmetric construction of N-heterocycles by means of aza Diels-Alder reactions, Mannich reactions, Pictet-Spengler reactions and 1,3-dipolar cycloadditions is described. Also their application in the steric steering of carbo Diels-Alder reactions, radicalic transformations and enantioselective nucleophilic additions to carbonyl groups is highlighted.

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