Synthesis 1994; 1994(12): 1429-1432
DOI: 10.1055/s-1994-25707
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Chiral Ligands Containing Heteroatoms; 12.1 Synthesis of Optically Active 2-Amino-2-(2′-pyridyl)-1-alkanols from β-Hydroxy-α-amino Acids

Sergio Cossu* , Sandra Conti, Giampaolo Giacomelli, Massimo Falorni
  • *Dipartimento di Chimica, Università degli Studi di Sassari, Via Vienna 2, I-07100 Sassari, Italy
Further Information

Publication History

Publication Date:
25 April 2002 (online)

The synthesis of a new class of optically active ligands such as the title compounds is presented. All the multistep procedures adopted start by the conversion of L-serine and L-threonine into the proper 2,2-dimethyloxazolidines, followed by transformation of the corresponding nitriles to pyridines. The reaction sequence occurs without loss of enantiomeric purity and with overall satisfactory yield.