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Synthesis 1994; 1994(10): 1026-1028
DOI: 10.1055/s-1994-25629
short paper
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Diastereoselective Synthesis of the C 2-Symmetric 2,3-Diaminotetralin via Electrophilic Amination

Peter Gmeiner* , Evi Hummel
  • *Pharmazeutisches Institut der Universität Bonn, An der Immenburg 4, D-53121 Bonn, Germany
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Publication Date:
27 September 2002 (online)

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Starting from the N,N-dibenzyl protected ß-amino acid 3 a synthesis of the C 2-symmetric racemic 2,3-diaminotetralin (4; 2,3- diamino-1,2,3,4-tetrahydronaphthalene) is reported. The key step of the procedure is a highly stereocontrolled electrophilic amination by dibenzyl azodicarboxylate.

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