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Synthesis 1994; 1994(6): 619-623
DOI: 10.1055/s-1994-25535
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Single-Step Synthesis of Racemic Di- and Tripeptides Derived from Unnatural β-Hydroxy and β-Mercapto α-Amino, Acids by the Ugi Reaction

M. Hatam* , D. Tehranfar, J. Martens
  • *Fachbereich Chemie, Universität Oldenburg, P.O. Box 2503, D-26111 Oldenburg, Germany
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Publication Date:
17 September 2002 (online)

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An efficient single-step selective synthesis of oligopeptide analogues, which contain amino acid analogues and are derivatives of 3-thiazolidines and 3-oxazolidine, through the use of hydrochloric acid as the protecting agent is described. These compounds are prepared based on the Ugi four component condensation (4CC) reaction.