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Synlett 1994; 1994(11): 929-930
DOI: 10.1055/s-1994-23051
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Lipase-Catalyzed Synthesis of Optically Active N,N,N,-Trimethylethanaminium α-Tocopherol Analog MDL-73404

Eisaku Mizuguchi* , Tetsuko Suzuki, Kazuo Achiwa
  • *School of Pharmaceutical Sciences University of Shizuoka, 52-1Yada, Shizuoka 422, Japan
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Publication Date:
22 March 2002 (online)

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Optically active 3,4-dihydro-6-hydroxy-N,N,N,2,5,7,8,-heptamethyl-2H-1-benzopyran-2-ethanaminium 4-methylbenzenesulfonate MDL-73404 was synthesized by kinetic resolution of racemic chromanethanols with lipase. The unnecessary (R)-chromanethanol as by-product of resolution was inverted to the (S)-isomer that could be treated as substrate for repeated lipase-catalyzed resolution.

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