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Synlett 1994; 1994(3): 206-208
DOI: 10.1055/s-1994-22796
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Synthesis of two Rigid Diacylglycerol Analogues Having a 1,7-Dioxasjuro[4.4]nonane Bis-γ-butyrolactone Skeleton.4.1

Jeewoo Lee* , Victor E. Marquez, Nancy E. Lewin, Peter M. Blumberg
  • *Laboratory of Medicinal Chemistry, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, NIH, Bethesda, Maryland 20892 (USA)
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Publication Date:
22 March 2002 (online)

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The stereoselective synthesis of two new bis-γ-butyrolactones, constructed on a dioxaspiro[4.4]nonane template, was efficiently completed in 11 steps from L-xylose. One of two isomers (2a) showed good binding affinity towards protein kinase C.

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