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Synlett 1994; 1994(1): 63-64
DOI: 10.1055/s-1994-22739
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Use of 4- Nitro-N-phthalimide as Protective Group of Primary Amines

Hidetsugu Tsubouchi* , Koichi Tsuji, Hiroshi Ishikawa
  • *Microbiological Research Institute, Otsuka Pharmaceutical Co., Ltd., Kagasuno 463-10, Kawauchi-cho, Tokushima 771-01, Japan.
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Publication Date:
22 March 2002 (online)

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The utility of 4-Nitrophthaloyl protection of amino groups is reported. This protecting function can be removed easily by methylhydrazine under mild conditions to afford the corresponding amines, amino acids, and azetidinones.

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