Synlett 1993; 1993(1): 63-64
DOI: 10.1055/s-1993-22350
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Enantioselective Synthesis of (R)-(-)-Baclofen

Angèle Schoenfelder* , André Mann, Sylvie Le Coz
  • *Laboratoire de Pharmacochimie Moléculaire, Centre de Neurochimie, 5, rue Blaise Pascal, F-67084 Strasbourg Cedex, France
Further Information

Publication History

Publication Date:
19 March 2002 (online)

An enantioselective synthesis of (R)-baclofen is presented. The chiral imide 2 was alkylated via its imide enolate with ten-butyl bromoacetate. Removal of the chiral auxiliary provided the lactone 5 and further transformations the lactam 8, which could be transformed in (R)-baclofen.