Enantioselective Synthesis of (R)-(-)-Baclofen
19 March 2002 (online)
An enantioselective synthesis of (R)-baclofen is presented. The chiral imide 2 was alkylated via its imide enolate with ten-butyl bromoacetate. Removal of the chiral auxiliary provided the lactone 5 and further transformations the lactam 8, which could be transformed in (R)-baclofen.