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Synthesis 1992; 1992(12): 1219-1220
DOI: 10.1055/s-1992-26341
short paper
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A New Method for Converting Nitriles into Primary Thioamides by Sodium Trimethylsilanethiolate

Pen-Yuan Lin* , Wei-Shan Ku, Min-Jen Shiao
  • *Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan, Republic of China
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Publikationsdatum:
29. April 2002 (online)

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A new method was developed for converting nitriles into primary thioamides. Treatment of various nitriles 1 with 1.5-2.5 equivalents of sodium trimethylsilyl sulfide (sodium trimethylsilanethiolate) in 1,3-dimethyl-2-imidazolidinone at 20-35°C for 4-30 hours gave the corresponding thioamides 2 in 27-80 % yield.