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Synthesis 1992; 1992(3): 293-296
DOI: 10.1055/s-1992-26095
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An Efficient One-Pot Synthesis of Pyrrolo[4,3,2-ij]isoquinoline Derivatives by a Consecutive Aza-Wittig/Electrocyclic Ring-Closure/Intramolecular Acylation Process

Pedro Molina* , Mateo Alajarín, Angel Vidal
  • *Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Murcia, Campus de Espinardo, E-30071, Murcia, Spain
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Publication Date:
17 September 2002 (online)

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Iminophosphorane, ethyl 5-ethoxycarbonyl-2-methoxy-α-[(triphenylphosphoranylidene) amino]cinnamate (4) reacts with aliphatic and aromatic isocyanates in toluene at 170°C to give directly the corresponding pyrrolo[4,3,2-ij]isoquinolines 8 in moderate yields.