Synlett 1992; 1992(1): 87-88
DOI: 10.1055/s-1992-21277
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Convenient Regioselective Synthesis of 4,6-Diaryl-3-cyano-2-hydroseleno-1,4-dihydropyridines

V. P. Litvinov* , Yu. A. Sharanin, A. M. Shestopalov, V. D. Dyachenko
  • *N. D. Zelinsky Institute of Organic Chemistry, Academy of Sciences, SU-117913, Moscow, Leninsky prospect 47, USSR
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Publication History

Publication Date:
18 September 2002 (online)

The reactions of chalcones 1 with 2-cyanoselenoacetamide, or of 3-aroyl-2-aryl-1,1-dicyanopropanes 3 with hydrogen selenide, in the presence of N-methylmorpholine give 4,6-diaryl-3-cyano-1,4-dihydropyridine-2-selenolate salts 4 in good yield. On acidification the latter are transformed into 4,6-diaryl-3-cyano-2-hydroseleno-1,4-dihydropyridines 5, which on dehydrogenation give 4,6-diaryl-3-cyanopyridine-2(1H)-selones 6.

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