Synlett 1992; 1992(1): 79-80
DOI: 10.1055/s-1992-21273
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Synthesis of 7-Formylindole Using the Bartoli Indole Methodology

David R. Dobson* , Jeremy Gilmore, David A. Long
  • *Chemistry Department, Eli Lilly and Co. Ltd., Lilly Research Centre Ltd., Erl Wood Manor, Windlesham, Surrey GU20 6PH, England
Further Information

Publication History

Publication Date:
18 September 2002 (online)

The Bartoli methodology provides a convenient route for the synthesis of 7-formylindole, either indirectly via an improved metalation of 7-bromoindole using sodium hydride/butyllithium or two equivalents of butyllithium or directly by use of an acetal protected 2-nitrobenzaldehyde and vinylmagnesium bromide.

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