Download PDF
Synthesis 1991; 1991(4): 303-306
DOI: 10.1055/s-1991-26450
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Polycyclic N-Hetero Compounds; XXXIX: A Facile Synthesis of 1,2,4,5-Tetrahydro-[1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidines via Ring Closure of 4-(2-Hydroxyalkylamino)-5,6-dihydro-[1]benzoxepino[5,4-d]pyrimidines

Tomohisa Nagamatsu* , Shogo Tsurubayashi, Kenji Sasaki, Takashi Hirota
  • *Faculty of Pharmaceutical Sciences, Okayama University, Tsushima 700, Japan
Further Information

Publication History

Publication Date:
29 April 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

The first example of the unknown [1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidine ring system is demonstrated as a new class of potent anit-platelet aggregation agents. That is, the 1,2,4,5-tetrahydro-[1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidines 11a-c were prepared by ring closure of 4-(2-hydroxyalkylamino)-5,6-dihydro-[1]benzoxepino[5,4-d]pyrimidines 10a-c with phosphoryl chloride.

      >