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Synlett 1991; 1991(8): 557-558
DOI: 10.1055/s-1991-20795
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Methylthiomethylation of Carbonyl Compounds Using Bis(trimethylsilylmethyl) Sulfide Promoted by Fluoride Ion1

Akira Hosomi* , Koichiro Ogata, Masakazu Ohkuma, Makoto Hojo
  • *Department of Chemistry, University of Tsukuba, Tsukuba, lbaraki 305, Japan
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Publication Date:
07 March 2002 (online)

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Bis(trimethylsilylmethyl) sulfide, readily prepared by the reaction of chloromethyltrimethylsilane with sodium sulfide in ethanol at reflux, reacts smoothly with carbonyl compounds by a fluoride ion promoted desilylation to afford the corresponding ß-substituted ß-hydroxyethyl methyl sulfides.

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