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Synlett 1991; 1991(8): 553-554
DOI: 10.1055/s-1991-20793
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A Useful Approach Towards Δ9-Tetrahydrocannabinol

Peter Stoss* , Peter Merrath
  • *Chemical Research and Development, Heinrich Mack Nachf., Chem.-Pharm. Fabrik, D-7918 Illertissen, Germany
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Publication History

Publication Date:
07 March 2002 (online)

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6,12-Dihydro-6-hydroxycannabidiol (3; 2-[6-(1-hydroxy-1-methylethyl)-3-methyl-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol) was isolated from the reaction of olivetol (1; 1-pentyl-3,5-dihydroxybenzene) and cis-p-menth-2-ene-1,8-diol (2). This pure, crystalline intermediate facilitates a directed synthesis of title compound 4 (6a,7,8,10a-tetrahydro-1-hydroxy-6,6,9-trimethyl-3-pentyl-6H-dibenzo[b,d]pyran).

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