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Synlett 1991; 1991(7): 515-516
DOI: 10.1055/s-1991-20784
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Kinetic Resolution of Chiral Imidazolidinones Using Homochiral Lithium Amide Bases

Peter Coggins* , Nigel S. Simpkins
  • *Department of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, England
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Publication Date:
07 March 2002 (online)

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A racemic imidazolidinone (1-tert-butoxycarbonyl-2-tert-butyl-3-methyl-4-imidazolidinone) has been subjected to kinetic resolution using a homochiral lithium amide base [lithium (R,R)-bis(1-phenylethyl)amide], thus enabling access to the optically active material in up to 80 % enantiomeric excess.