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Synlett 1990; 1990(9): 537-539
DOI: 10.1055/s-1990-21991
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Reductive Amination of Aldehydes and Ketones with Weakly Basic Anilines Using Sodium Triacetoxyborohydride

Ahmed F. Abdel-Magid* , Cynthia A. Maryanoff
  • *R. W. Johnson Pharmaceutical Research Institute, Department of Chemical Development, Spring House, Pennsylvania 19477, USA
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Publication Date:
08 March 2002 (online)

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The weakly basic chloro-, nitro-, cyano-, ethoxy- carbonyl- and carboxy-substituted anilines react with aldehydes and ketones under reductive amination conditions, employing sodium triacetoxyborohydride, to give excellent yields of the corresponding secondary aromatic amines.

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