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Synlett 1990; 1990(12): 749-750
DOI: 10.1055/s-1990-21237
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Direct Substitution of 2-Phenylsulphonylpyrrolidines, -piperidines, -tetrahydrofurans and -tetrahydropyrans by Alkyl Organometallic Reagents in Dichloromethane

Dearg S. Brown* , Philippe Charreau, Steven V. Ley
  • *Department of Chemistry, Imperial College of Science, Technology and Medicine, South Kensington, London, SW7 2AY, England
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Publication Date:
08 March 2002 (online)

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Treatment of 2-phenylsulphonylpyrrolidines, -piperidines, -tetrahydrofurans and -tetrahydropyrans in dichloro-methane with alkyl organometallic reagents prepared from the Grignard reagents and zinc chloride affords the corresponding substitution products in moderate to excellent yield.

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