Synlett 1989; 1989(1): 55-57
DOI: 10.1055/s-1989-34708
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An Improved Procedure for Bromomethylation of Aromatics Using Phase-Transfer Catalysis. Rapid Bis-haloalkylation

Reginald H. Mitchell* , Vivekanantan S. Iyer
  • *Department of Chemistry, University of Victoria, Victoria, British Columbia, V8W 2Y2, Canada
Further Information

Publication History

Publication Date:
26 February 2002 (online)

Bromomethylation of aromatic hydrocarbons proceeds in >90% yield using the phase-transfer catalyst tetradecyltri-methylammonium bromide with 1,3,5-trioxane and a mixture of 48% aqueous hydrobromic acid and glacial acetic acid; diaryl-methane by-products are not formed.