Synlett 1989; 1989(1): 70-71
DOI: 10.1055/s-1989-34702
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Transition-Metal Binding Site of Bleomycin. A Synthetic Analogue Superior to Bleomycin in Dioxygen-Activating Capability1

Akira Suga* , Toru Sugiyama, Yuichi Sugano, Atsushi Kittaka, Masami Otsuka, Masaji Ohno, Yukio Sugiura, Kenji Maeda
  • *Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan
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26. Februar 2002 (online)

A synthetic model compound for the metal-binding site of bleomycin with a 4-dimethylaminopyridine nucleus and a tert-butyl ether group shows dioxygen activation up to 125% of that of natural bleomycin.