Synlett 1989; 1989(1): 70-71
DOI: 10.1055/s-1989-34702
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Transition-Metal Binding Site of Bleomycin. A Synthetic Analogue Superior to Bleomycin in Dioxygen-Activating Capability1

Akira Suga* , Toru Sugiyama, Yuichi Sugano, Atsushi Kittaka, Masami Otsuka, Masaji Ohno, Yukio Sugiura, Kenji Maeda
  • *Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
26.Februar 2002 (online)

A synthetic model compound for the metal-binding site of bleomycin with a 4-dimethylaminopyridine nucleus and a tert-butyl ether group shows dioxygen activation up to 125% of that of natural bleomycin.