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Synlett 1989; 1989(1): 62-63
DOI: 10.1055/s-1989-34688
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Ruthenium-Catalyzed Oxidation of Nitriles with tert-Butyl Hydroperoxide

Shun-Ichi Murahashi* , Takeshi Naota, Toshiyuki Kuwabara
  • *Department of Chemistry, Faculty of Engineering Science, Osaka University, Machikaneyama, Toyonaka, Osaka, 560 Japan
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Publikationsdatum:
26. Februar 2002 (online)

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The ruthenium-catalyzed reaction of α-substituted nitriles 1 with t-BuOOH gives 2-(tert-butyldioxy)alkanenitriles 2 efficiently, while that of nitriles 3 gives acyl cyanides 4. The present reactions provide novel methods for the transformation of nitriles to cyanohydrins and ketones upon catalytic hydrogenation of 2, and titanium-induced reaction of 2, respectively.

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