Asymmetric 1,2- and 1,3-Inductions and Solvent Dependence Found in Chelate-Controlled Additions of Grignard Reagents and Cuprates to Chiral β-Formyl Esters. Stereoselective Synthesis of γ-Lactones
26 February 2002 (online)
The stereoselectivity of cuprate or Grignard reagent additions to chiral β-formyl esters 1, 3, and 5 highly depends on the solvent employed. Also, the substitution pattern of the aldehyde determines whether the cis- or trans-γ-lactone is the major product.