Synlett 1989; 1989(1): 42-45
DOI: 10.1055/s-1989-34685
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Cembranoid Synthesis Using Ketophosphonate - Aldehyde Crclization: Syntheses of Thunbergols and α- and β-Cembra-2,7,11-triene-4,6-diols

Peter C. Astles* , Eric J. Thomas
  • *Department of Chemistry, University of Manchester, Manchester, M13 9PL, England
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Publication History

Publication Date:
26 February 2002 (online)

Cyclization of the ketophosphonate 18 was efficient and led to the thunbergols 3 and 4. Cyclization of the protected hydroxyphosphonate 28 was less efficient, but gave the cyclic ketone 29, a precursor of the cembratrienediols 1 and 2, with little racemization at C-1.