Synthesis 1989; 1989(12): 946-949
DOI: 10.1055/s-1989-27440
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A Synthesis of N-Substituted ß-Alanines: Michael Addition of Amines to Trimethylsilyl Acrylate

Stefan Kwiatkowski* , Azhwarsamy Jeganathan, Thomas Tobin, David S. Watt
  • *Department of Chemistry, Department of Veterinary Science, and Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, KY 40506, USA
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Publication History

Publication Date:
02 May 2002 (online)

The Michael addition of primary and secondary amines 2 to tromethylsilyl acrylate (1) afforded ß-(alkylamino)- and ß-(dialkylamino)-propionic acids 4, respectively, in good yield.

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